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[Expression of pSTAT3 in non-small cell lung cancer and its clinical significance]
Rui-juan Wang1, Jian-zhong Zhang, Ping Wang
1Department of Respiratory Diseases, The 306th Hospital of PLA, Beijing, China. wangruijuan1129@126.com
Aim:
To explore the expression of phosphorylated STAT3 (pSTAT3) in non-small cell lung cancer(NSCLC) and its clinical significance.
Methods:
The expression of pSTAT3 was detected in 59 cases of NSCLC and their para-cancerous tissue by immunohistochemical staining.
Results:
(1) The expression of pSTAT3 in NSCLC was significantly higher than that in para-cancerous tissue. (2) The expression of pSTAT3 was associated with tumor's size and smoking status, which was significantly higher in smaller tumors(diameter<3 cm) and nonsmokers than that in larger tumors(diameter≥3 cm) and smokers, but was not associated with gender, age, lymph node metastasis, clinical stage and differentiation grade. The percentage rate of pSTAT3 expression was higher in adenocarcinoma than that in squamous cell carcinoma but without statistically significant.
Conclusion:
pSTAT3 may play an important role in the development of NSCLC and the direction of targeted therapy.