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Metabolic Labeling and Profiling of Transfer RNAs Using Macroarrays
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Carbohydrate deficient transferrin in a driver's license regranting program.

Thomas M Maenhout1, Guido Baten, Marc L De Buyzere

  • 1Department of Clinical Chemistry, Ghent University Hospital, Belgium.

Alcohol and Alcoholism (Oxford, Oxfordshire)
|March 8, 2012
PubMed
Summary

Carbohydrate deficient transferrin (CDT) is an effective marker for detecting chronic alcohol abuse in traffic medicine. A new cut-off value of 2.3% CDT successfully reduced driver

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Area of Science:

  • Forensic Toxicology
  • Clinical Chemistry
  • Traffic Medicine

Background:

  • Carbohydrate deficient transferrin (CDT) is a validated biomarker for chronic alcohol abuse.
  • CDT has been implemented in Belgium's traffic medicine for driver's license renewal and regranting over 2.5 years.
  • Establishing a reliable cut-off is crucial for effective application in forensic contexts.

Purpose of the Study:

  • To evaluate the efficacy of CDT as a marker for chronic alcohol abuse in driver's license applicants.
  • To determine an applicable CDT cut-off value for forensic use in traffic medicine.
  • To assess the impact of the CDT-based program on driver's license regranting outcomes.

Main Methods:

  • CDT levels were measured in 3977 subjects using capillary zone electrophoresis (Capillarys 2™ system).
  • A CDT cut-off value was determined using Bhattacharya statistics with a measurement uncertainty interval.
  • Program outcomes were evaluated by monitoring CDT values in 163 subjects over one year.

Main Results:

  • A general CDT cut-off of 2.3% was established for the study population.
  • While males had higher CDT values, a gender-specific cut-off was not deemed necessary.
  • A separate cut-off was suggested for drivers under 30 due to lower CDT values.
  • The percentage of offenders decreased from 29% to 8% within one year of program implementation.

Conclusions:

  • CDT serves as a powerful tool for identifying chronic alcohol abuse in the context of driver's license renewal.
  • The established 2.3% CDT cut-off proved effective in evaluating the program's success.
  • The driver's license regranting program demonstrated a favorable outcome over 2.5 years of data collection.