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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Nanostructural features of diabetic podocytopathy
1Department of Nephropathology, Carol Davila Clinical Hospital for Nephrology, Bucharest, Romania. mandache.eugen@yahoo.com
Abstract:
The earliest glomerular lesion during the diabetic nephropathy is considered by many authors to be the so-called podocytopathy. Microalbuminuria is an early clinical marker of diabetic nephropathy that results from damages of the glomerular filtration barrier at the level of the highly differentiated podocytes. Thus, the diabetic podocytopathy includes cellular hypertrophy, foot process effacement, detachment from glomerular basement membrane (GBM), and apoptosis. The present paper is reviewing all these features and some additional ultrastructural transformations concerning the podocytes involved in the diabetic kidney disease.
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