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Updated: May 24, 2026

Quantifying Pulmonary Microvascular Density in Mice Across Lobules
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Microvascular density in non-Hodgkin B-cell lymphomas measured using digital morphometry.

T Mezei1, Emoke Horváth, M Turcu

  • 1Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania. tmezei@pathologia.ro

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|March 8, 2012
PubMed
Summary

Angiogenesis, the formation of new blood vessels, is crucial for tumor growth. This study found significant differences in blood vessel size and density between diffuse large B-cell lymphoma and follicular lymphoma, suggesting varying angiogenic potential.

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Area of Science:

  • Oncology
  • Vascular Biology
  • Pathology

Background:

  • Tumor expansion relies on angiogenesis, the development of microvessels for nutrient supply and waste removal.
  • Tumor microvasculature facilitates tumor cell metastasis.
  • Endothelial cells within tumors can support tumor cell growth via paracrine signaling.

Purpose of the Study:

  • To review literature on angiogenesis in malignant lymphomas.
  • To conduct digital morphometric analysis of angiogenesis in large B-cell lymphomas and follicular lymphomas.

Main Methods:

  • Literature review on angiogenesis assessment methods.
  • Digital morphometry on 19 lymphoma cases using CD34 immunohistochemistry.
  • Measurement of average vascular diameter and endothelial area.

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Last Updated: May 24, 2026

Quantifying Pulmonary Microvascular Density in Mice Across Lobules
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Main Results:

  • Significant differences in average vascular diameter between diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).
  • High-grade lymphomas exhibited a greater CD34+ endothelial area compared to low-grade lymphomas.
  • Angiogenesis plays a key role in tumor biology, with potential therapeutic implications.

Conclusions:

  • Morphometric analysis reveals distinct angiogenic profiles in DLBCL and FL.
  • Understanding lymphoma angiogenesis may lead to novel therapeutic strategies.
  • Further research into lymphoma angiogenesis is warranted.