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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
P53, p16 and Ki67 immunoexpression in oral squamous carcinomas
L P Dragomir1, Cristiana Simionescu, Cl Mărgăritescu
1Department of Occlusology Dental Prosthetics, University of Medicine and Pharmacy of Craiova, Romania.
Summary
This study analyzed oral squamous cell carcinoma (OSCC) and adjacent dysplasia. Ki67 expression correlated with lower differentiation and higher dysplasia, while p16, p53, and Ki67 showed increased expression at critical lesion sites.
Area of Science:
- Oral pathology
- Oncology
- Cancer biomarkers
Background:
- Oral squamous cell carcinoma (OSCC) is a significant global health concern.
- Early detection of precancerous lesions, such as epithelial dysplasia, is crucial for improving patient outcomes.
- Understanding the molecular markers associated with OSCC progression is vital for targeted therapies.
Purpose of the Study:
- To investigate the clinical, histopathological, and immunohistochemical features of OSCC.
- To evaluate the expression of p53, p16, and Ki67 in OSCC and adjacent dysplastic lesions.
- To determine the correlation between these markers and clinicopathological parameters.
Main Methods:
- Analysis of 34 OSCC cases, with 11 showing adjacent epithelial dysplasia.
- Clinical, histopathological, and immunohistochemical evaluation.
- Assessment of immunoexpression for p53, p16, and Ki67.
Main Results:
- Predominance of well-differentiated OSCC in early stages (I/II).
- Ki67 expression inversely correlated with tumor differentiation and positively with high-grade dysplasia.
- Increased p16 expression in dysplastic epithelium; increased p53 and Ki67 at the tumor invasion front.
Conclusions:
- p16 immunostaining is valuable for identifying dysplastic lesions.
- p53 and Ki67 hold predictive importance for aggressive OSCC forms.
- Immunohistochemical markers aid in understanding OSCC biology and progression.
