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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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Published on: July 29, 2021

Developmental changes in human dural innervation.

J R Davidson1, J Mack, A Gutnikova

  • 1Department of Neuropathology, John Radcliffe Hospital, Oxford, UK.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|March 8, 2012
PubMed
Summary
This summary is machine-generated.

Human dura mater innervation density changes significantly with age, increasing during fetal development and decreasing after birth. This study reveals crucial age-related changes in the dura

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Human Anatomy

Background:

  • The human dura mater's innervation and function, particularly its role in venous blood outflow and sensory input via the trigeminal nerve, are not well-documented.
  • The trigeminal nerve plays a vital role in fetal development, mediating essential reflexes like sucking and swallowing.
  • Limited research exists on age-related changes in the dura mater's nerve density and its implications.

Purpose of the Study:

  • To investigate age-related alterations in the innervation density of the human dura mater.
  • To provide new insights into the functional significance of the dura mater during human development.

Main Methods:

  • Examined dura mater samples from 27 individuals, ranging from 31 weeks gestation to 60 years old.
  • Employed immunocytochemistry with neurofilament antibodies to quantify nerve density.

Main Results:

  • Dural innervation density increased from 31 weeks gestation, peaking at term.
  • A decline in innervation density was observed in the first three months postpartum, remaining low thereafter.
  • Significant age-related changes in human dural innervation density were identified.

Conclusions:

  • This study presents the first evidence of age-related changes in human dural innervation density.
  • Findings align with animal studies, offering novel insights into the dura mater's developmental functions.
  • The observed changes in innervation suggest dynamic roles for the dura mater throughout human life.