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Related Experiment Video

Updated: May 24, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cell therapy in chronic liver disease.

Taro Takami¹, Shuji Terai, Isao Sakaida

¹Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Yamaguchi, Japan.

Current Opinion in Gastroenterology

|March 8, 2012

Summary

Infusing bone marrow cells shows promise for improving liver function in cirrhosis patients. Further research into less-invasive cultured cell therapies is needed for advanced liver regeneration.

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Area of Science:

Hepatology
Regenerative Medicine
Cell Therapy

Background:

Liver cirrhosis is a significant health concern with limited treatment options.
Current research focuses on regenerative approaches to restore liver function.

Purpose of the Study:

To review current liver regeneration therapies for cirrhosis.
To discuss future prospects in liver disease treatment.

Main Methods:

Review of clinical studies involving cell administration (e.g., CD34+, CD133+, mesenchymal stem cells).
Analysis of autologous bone marrow cell infusion (ABMi) therapy and its reported outcomes.
Examination of preclinical data and clinical efficacy of various cell-based interventions.

Main Results:

Clinical studies demonstrate effectiveness of cell therapies in some liver cirrhosis patients.
Autologous bone marrow cell infusion (ABMi) has shown improved liver fibrosis and function in preclinical and clinical settings.
Efficacy and safety of ABMi therapy are supported by findings from multiple institutions.

Conclusions:

Recent clinical data suggest bone marrow cell infusion can improve liver function in cirrhosis.
Development of novel, less-invasive treatments using cultured bone marrow-derived cells is recommended.