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Updated: May 24, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
The cellular and signaling networks linking the immune system and metabolism in disease
Olivia Osborn1, Jerrold M Olefsky
1Department of Medicine, Division of Endocrinology and Metabolism, University of California-San Diego, La Jolla, California, USA.
Abstract:
It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated. Recent advances in deciphering the various cellular and signaling networks that participate in linking the immune and metabolic systems together have contributed to understanding of the pathogenesis of metabolic diseases and may also inform new therapeutic strategies based on immunomodulation. Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.
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