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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Bladder tissue engineering using biocompatible nanofibrous electrospun constructs: feasibility and safety
Nasser Shakhssalim1, Mohammad Mehdi Dehghan, Reza Moghadasali
1Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urology Journal
|March 8, 2012
Summary
This study explored nanofibrous scaffolds for bladder tissue engineering in dogs. The poly(lactic acid)/polycaprolactone (PLLA/PCL) scaffold showed promising results with low body response and favorable clinical outcomes.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Veterinary Surgery
Background:
- Tissue engineering aims to regenerate damaged tissues.
- Biodegradable polymers like polycaprolactone (PCL) and polylactic acid (PLLA) are promising biomaterials.
- Developing suitable scaffolds is crucial for successful tissue regeneration.
Purpose of the Study:
- To assess the feasibility and safety of electrospun PCL and PLLA/PCL nanofibrous mats for bladder tissue engineering.
- To evaluate the in vivo performance of these scaffolds in a canine model.
Main Methods:
- Plasma-treated, unseeded electrospun PCL and PLLA/PCL mats were implanted in three dogs.
- Grafts were explanted at 3 and 4 months post-implantation.
- Macroscopic, morphological, histochemical, immunohistochemical, and scanning electron microscopy evaluations were performed.
Main Results:
- Both PCL and PLLA/PCL mats demonstrated significant cell infiltration and tissue formation.
- The PLLA/PCL mat elicited a lower body response compared to the PCL mat.
- While all models showed similar microscopic findings, the PLLA/PCL scaffold exhibited favorable clinical results.
Conclusions:
- Nanofibrous PLLA/PCL scaffolds show potential as suitable materials for bladder tissue engineering.
- Further research is warranted to fully elucidate the capabilities of PLLA/PCL scaffolds in regenerative medicine.
