Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A blood based mitochondrial functional index biomarker for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

A Blood Based Mitochondrial Functional Index Biomarker for Alzheimer's Disease.

medRxiv : the preprint server for health sciences·2025
Same author

Delivery of a STING Agonist Using Lipid Nanoparticles Inhibits Pancreatic Cancer Growth.

International journal of nanomedicine·2024
Same author

Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation.

Biomolecules·2023
Same author

Physician Moms: Too Many Hats to Wear.

Missouri medicine·2023

Related Experiment Video

Updated: May 24, 2026

Efficiently Recording the Eye-Hand Coordination to Incoordination Spectrum
07:30

Efficiently Recording the Eye-Hand Coordination to Incoordination Spectrum

Published on: March 21, 2019

Preferred retinal locus--hand coordination in a maze-tracing task.

George T Timberlake1, Evanthia Omoscharka, Susan A Grose

  • 1Kansas City Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA. gtimberl@kumc.edu

Investigative Ophthalmology & Visual Science
|March 8, 2012
PubMed
Summary

The preferred retina locus for fixation (fPRL) guides hand movements in fine motor tasks, even with age-related macular degeneration (AMD) related vision loss. This fPRL guidance is crucial for visuomotor coordination in tasks like maze tracing.

More Related Videos

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents
04:41

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Related Experiment Videos

Last Updated: May 24, 2026

Efficiently Recording the Eye-Hand Coordination to Incoordination Spectrum
07:30

Efficiently Recording the Eye-Hand Coordination to Incoordination Spectrum

Published on: March 21, 2019

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents
04:41

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Human Motor Control

Background:

  • Fine manual tasks demand precise integration of visual input, eye movements, and motor output.
  • Age-related macular degeneration (AMD) can cause macular scotomas, potentially disrupting this visual-motor coordination.
  • The role of the preferred retina locus for fixation (fPRL) in guiding manual tasks, especially in individuals with AMD, is not fully understood.

Purpose of the Study:

  • To investigate if the fPRL directs hand movements during fine manual tasks.
  • To examine the interplay between the fPRL, fingertip position, and scotomas in AMD patients during task performance.
  • To compare visuomotor control in individuals with AMD and normally sighted controls.

Main Methods:

  • Participants with AMD-induced macular scotomas and healthy controls performed a maze-tracing task using their index finger.
  • The task was conducted within a scanning laser ophthalmoscope (SLO) to simultaneously view the hand and maze on the retina.
  • Retinal images were analyzed to map scotoma locations, fPRL positions, and fingertip trajectories.

Main Results:

  • Fingertip retinal positions were centered around the fPRL, indicating fPRL-guided hand movements.
  • The size of the fingertip retinal ellipse correlated with the fPRL ellipse size.
  • For scotoma subjects, maze-tracing accuracy was positively associated with saccade rate.

Conclusions:

  • The fPRL, similar to the fovea in normally sighted individuals, guides the fingertip during visuomotor tasks like maze tracing.
  • While fPRL guides the hand, other factors likely contribute to the reduced maze-tracing performance observed in individuals with AMD.
  • Findings highlight the adaptive role of the fPRL in visuomotor control despite central vision loss.