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A study of factors associated with cerebral venous thrombosis

Mehdi Jalili1, Shadi Ghourchian, Gholam Ali Shahidi

  • 1Tehran University of Medical Sciences, Hemmat Expressway, Tehran, Iran.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 8, 2012
PubMed

Insights

Cerebral venous thrombosis (CVT) is a rare stroke cause, predominantly affecting young females. Key risk factors include pregnancy and fasting, with seizures and intracranial hemorrhage linked to higher mortality.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Epidemiology

Background:

  • Cerebral venous thrombosis (CVT) is an uncommon yet significant cause of stroke.
  • Limited research exists on CVT risk factors, necessitating further investigation.

Purpose of the Study:

  • To investigate risk factors, mortality, clinical presentation, imaging findings, and seasonal distribution of CVT in Iranian patients.
  • To identify predictors of seizure and mortality in CVT patients.

Main Methods:

  • Retrospective cross-sectional study of 62 CVT patients over 12 years (1997-2010) at a referral neurology center.
  • Data collected via checklist including demographics, risk factors, venous involvement, and outcomes.
  • Statistical analysis to determine significant relationships between variables.

Main Results:

  • CVT predominantly affected females (85.5%) aged 25-35.
  • Superior sagittal sinus was the most common site of thrombosis (35 patients).
  • Generalized seizures (P = 0.017), intracranial hemorrhage, fasting, and pregnancy were associated with increased mortality and seizures.

Conclusions:

  • CVT presents unique risk factors and clinical manifestations in the studied Iranian population.
  • Pregnancy, fasting, seizures, and intracranial hemorrhage are critical factors influencing CVT outcomes.
  • Findings support targeted interventions and further research for CVT management.

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