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Multifocal Electroretinograms
Published on: December 4, 2011
Stiles-Crawford effect in focal macular ERGs from macaque monkey
Celso Soiti Matsumoto1, Kei Shinoda, Harue Matsumoto
1Department of Ophthalmology, Faculty of Medicine, Oita University, Oita, Japan.
Journal of Vision
|March 8, 2012
Summary
Focal macular electroretinograms (FMERGs) are affected by light incidence angle, confirming the Stiles-Crawford effect (SCE) in monkeys. This finding offers a new method for assessing cone alignment in human macular diseases.
Area of Science:
- Ophthalmology
- Neuroscience
- Vision Science
Background:
- Investigating the Stiles-Crawford effect (SCE) using focal macular electroretinograms (FMERGs).
- Determining if light incidence angle on the retina influences FMERG responses.
Purpose of the Study:
- To ascertain the impact of light incidence angle on FMERGs.
- To validate the detection of the Stiles-Crawford effect (SCE) in macaque monkeys via FMERGs.
Main Methods:
- Eliciting FMERGs through focal macula stimulation in three light-adapted macaque monkeys.
- Varying the light incidence angle on the retina from 0 to ±11.7°.
- Analyzing the effects of incidence angle and stimulus wavelengths on the SCE.
Main Results:
- FMERG component amplitudes peaked when the stimulus beam entered the eye along the visual axis and pupil center.
- Amplitudes decreased as the stimulus beam passed eccentrically through the pupil, hitting the retina more obliquely.
- All FMERG components decreased, with the d-wave amplitude showing the least reduction.
Conclusions:
- The observed decrease in FMERG amplitudes with increasing light incidence angle confirms the SCE in macaque monkeys.
- This objective FMERG-based method for assessing SCE suggests potential for evaluating human cone alignment in macular diseases.
