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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

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The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 24, 2026

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

Immunity, cancer and aging: lessons from mouse models.

Cheryl E Myers¹, Noweeda N Mirza, Joseph Lustgarten

¹Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, USA.

Aging and Disease

|March 8, 2012

Summary

Aging impairs immune function, reducing cancer immunotherapy effectiveness. This review explores age-related immune defects and strategies to optimize cancer immunotherapy in older populations.

Keywords:

Aging Cancer Immunity Immunotherapy Intervention

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Last Updated: May 24, 2026

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A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research

Published on: August 15, 2019

Area of Science:

Immunology
Oncology
Gerontology

Background:

Immune function declines with age, increasing cancer incidence.
Current cancer immunotherapy research often overlooks age-related immune changes.
Immunotherapy is less effective in older individuals compared to younger ones.

Purpose of the Study:

To review age-associated defects in the immune system impacting anti-tumor responses.
To discuss strategies for enhancing anti-tumor immunity in the elderly.
To present a preclinical model for optimizing immunotherapy in aged subjects.

Main Methods:

Literature review of age-related immune dysfunction.
Analysis of strategies to boost anti-tumor immune responses in aging.
Description of a preclinical tumor model for aged animals.

Main Results:

Identified specific defects in the aged immune system that hinder anti-tumor responses.
Outlined various strategies to overcome these age-related immune deficits.
Established a preclinical model to test optimized immunotherapy approaches.

Conclusions:

Age-related immune decline significantly impacts cancer immunotherapy efficacy.
Targeted strategies are necessary to improve immunotherapy outcomes in the elderly.
Preclinical models are crucial for developing effective age-tailored cancer treatments.