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Varying clinical features of Turkish Kawasaki disease patients

Bora Gülhan1, Selman Kesici, Serdar Beken

  • 1Division of 1Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|March 9, 2012
PubMed

Insights

Turkish children with Kawasaki disease (KD) show distinct clinical features, including delayed rash and earlier coronary artery aneurysm development. Diagnostic criteria performance was satisfactory, but variations suggest unique disease characteristics in this population.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Cardiology

Background:

  • Kawasaki disease (KD) is a critical pediatric vasculitis leading to coronary artery (CA) aneurysms.
  • Understanding ethnic variations in KD presentation is vital for timely diagnosis and management.

Purpose of the Study:

  • To describe the clinical characteristics of Turkish patients diagnosed with Kawasaki disease.
  • To evaluate potential differences in KD presentation and coronary artery involvement among Turkish children.

Main Methods:

  • Retrospective analysis of clinical data from 33 Turkish Kawasaki disease patients.
  • Assessment of symptom onset, physical findings, laboratory features, and coronary artery involvement.

Main Results:

  • Periungual peeling occurred in 42.4% of patients within 14 days of fever onset.
  • Coronary artery involvement was detected by an average of 12.3 days after fever onset, with 50% diagnosed within 8 days.
  • American Heart Association criteria showed 65.5% sensitivity for diagnosing KD in this cohort.

Conclusions:

  • Turkish Kawasaki disease patients may exhibit distinct clinical timelines, particularly regarding coronary artery aneurysm development.
  • The findings suggest potential ethnic variations in Kawasaki disease presentation that warrant further investigation.

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