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Updated: May 24, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Left ventricular noncompaction: clinical-echocardiographic study
Aleksandra Nikolić1, Ljiljana Jovović, Slobodan Tomić
1Faculty of Medicine, University of Belgrade, Belgrade, Serbia. nikolicdrsasa@gmail.com
Insights
Left ventricular noncompaction (LVNC) is a rare heart muscle disorder. This study found 12 cases in 3,854 outpatients, suggesting a potentially higher prevalence than previously thought.
Area of Science:
- Cardiology
- Cardiovascular Diseases
- Medical Diagnostics
Background:
- Left ventricular noncompaction (LVNC) is a rare endomyocardial morphogenesis disorder.
- It can occur in isolation or with congenital heart disease and neuromuscular diseases.
- LVNC is linked to high mortality, heart failure, arrhythmias, and thromboembolic events.
Purpose of the Study:
- To determine the prevalence of LVNC in outpatients.
- To analyze the clinical presentation of LVNC.
- To utilize clinical and echocardiographic findings for diagnosis.
Main Methods:
- A study of 3,854 consecutive outpatients from January 2006 to January 2007.
- Echocardiographic examinations were performed using Vivid 7 GE Medical System equipment.
- Analysis of echocardiographic parameters and clinical presentation in patients meeting LVNC criteria.
Main Results:
- Twelve out of 3,854 patients (0.31%) met the echocardiographic criteria for LVNC.
- The mean age at diagnosis was 45 years (±15 years), with 7 males.
- Seven patients showed signs of heart failure; six experienced arrhythmias, with no embolic events.
Conclusions:
- The prevalence of LVNC may be underestimated in the general population.
- Further research is needed to fully understand and address LVNC.
- Early recognition and diagnosis are crucial due to significant morbidity and mortality.
Background/Aim:
Left ventricular noncompaction (LVNC) is a disorder in endomyocardial morphogenesis, seen either isolated (in the absence of other cardiac anomalies) or in association with congenital heart disease and some neuromuscular diseases. Intrauterine arrest of the compaction of myocardial fibers is postulated to be the reason of LVNC. Recognition of this condition is extremely important due to its high mortality and morbidity that lead to progressive heart failure, ventricular arrhythmias and thromboembolic events. The aim of this study was to determine the prevalence and clinical presentation of LVNC among consecutive outpatients according to clinical and echocardiographyic findings.
Method:
A total of 3,854 consecutive patients examined at the Institute for Cardiovascular Diseases within a period January 2006 - January 2007 were included in the study. All the patients underwent echocardiographic examination using the same equipment (Vivid 7, GE Medical System). Echocardiographic parameters and clinical presentation in patients with echocardiographic criteria for LVNC were analyzed.
Results:
Analyzing 3,854 consecutive outpatients, using two-dimensional Color Doppler echocardiography from January 2006 to January 2007, 12 patients met the criteria for LVNC. Seven of them were male. The mean age at diagnosis was 45 +/- 15 years. Analyzing clinical manifestation of LVNC it was found that seven patients had signs of heart failure, six had arrhythmias with no embolic events.
Conclusion:
Our results suggest that the real prevalence of LVNC may be higher than expected. New studies have to be done to solve this problem.
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