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Growth, thermogenesis, and hyperphagia
1Department of Physics and Astronomy, University of New Mexico, Albuquerque 87131.
The American Journal of Clinical Nutrition
|November 1, 1990
Summary
Resting metabolic rate depends on fat-free mass and energy intake imbalances. A two-reservoir model shows fat-free mass grows rapidly, while fat stores grow slowly during hyperphagia.
Area of Science:
- Metabolic studies
- Physiological modeling
Background:
- Resting metabolic rate (RMR) is influenced by body composition and energy balance.
- Understanding energy partitioning during overfeeding is crucial for metabolic health.
Purpose of the Study:
- To model the relationship between RMR, fat-free mass, and energy intake.
- To analyze energy partitioning dynamics during hyperphagia using a two-reservoir model.
Main Methods:
- Utilized a two-reservoir energy model incorporating obligatory energy expenditure.
- Applied the model to simulate hyperphagia (excessive food intake).
Main Results:
- Fat-free mass growth is rapid and bounded, while fat store growth is slow and bounded.
- Initially, excess energy favors fat storage, but this shifts towards fat-free mass over time.
- Predicted weight gain per unit of excess energy decreases monotonically, approaching an asymptote.
Conclusions:
- The two-reservoir model provides insights into energy partitioning during hyperphagia.
- Long-term discrepancies suggest the increasing importance of facultative (adaptive) regulatory mechanisms in energy balance.