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Related Experiment Videos

Growth, thermogenesis, and hyperphagia.

S S Alpert1

  • 1Department of Physics and Astronomy, University of New Mexico, Albuquerque 87131.

The American Journal of Clinical Nutrition
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Resting metabolic rate depends on fat-free mass and energy intake imbalances. A two-reservoir model shows fat-free mass grows rapidly, while fat stores grow slowly during hyperphagia.

Area of Science:

  • Metabolic studies
  • Physiological modeling

Background:

  • Resting metabolic rate (RMR) is influenced by body composition and energy balance.
  • Understanding energy partitioning during overfeeding is crucial for metabolic health.

Purpose of the Study:

  • To model the relationship between RMR, fat-free mass, and energy intake.
  • To analyze energy partitioning dynamics during hyperphagia using a two-reservoir model.

Main Methods:

  • Utilized a two-reservoir energy model incorporating obligatory energy expenditure.
  • Applied the model to simulate hyperphagia (excessive food intake).

Main Results:

  • Fat-free mass growth is rapid and bounded, while fat store growth is slow and bounded.
  • Initially, excess energy favors fat storage, but this shifts towards fat-free mass over time.

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  • Predicted weight gain per unit of excess energy decreases monotonically, approaching an asymptote.

    • Conclusions:

    • The two-reservoir model provides insights into energy partitioning during hyperphagia.
    • Long-term discrepancies suggest the increasing importance of facultative (adaptive) regulatory mechanisms in energy balance.