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Related Experiment Video

Updated: May 24, 2026

Extracellular Vesicle Tissue Factor Activity Assay

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor and thrombin in sickle cell anemia.

Pichika Chantrathammachart¹, Rafal Pawlinski

¹Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Thrombosis Research

|March 9, 2012

Summary

Sickle cell anemia involves blood clotting issues that worsen inflammation and vascular damage. This review explores how tissue factor drives coagulation, thrombosis, and inflammation in sickle cell anemia patients.

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Last Updated: May 24, 2026

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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

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Published on: November 22, 2024

Area of Science:

Hematology
Vascular Biology
Coagulation Science

Background:

Sickle cell anemia is an inherited blood disorder with hemolytic and vaso-occlusive complications.
Coagulation activation is a significant feature of sickle cell anemia.
Coagulation is increasingly recognized for its role in inflammation and vascular injury in this condition.

Purpose of the Study:

This review examines the role of tissue factor in sickle cell anemia.
To elucidate the contribution of tissue factor to coagulation activation, thrombosis, and vascular inflammation.

Main Methods:

Literature review focusing on studies investigating tissue factor expression.
Analysis of research on the mechanisms linking tissue factor to coagulation and inflammation in sickle cell anemia.

Main Results:

Tissue factor expression is implicated in the hypercoagulable state of sickle cell anemia.
Tissue factor promotes coagulation cascade activation, leading to thrombosis.
Tissue factor contributes to the inflammatory processes and vascular damage observed in sickle cell anemia.

Conclusions:

Tissue factor plays a critical role in the pathogenesis of sickle cell anemia.
Targeting tissue factor may offer therapeutic strategies for managing coagulation and inflammation in sickle cell anemia.