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Updated: May 24, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Fast and sharp decrease in calprotectin predicts remission by infliximab in anti-TNF naïve patients with ulcerative
Infliximab induction therapy rapidly reduced fecal calprotectin in ulcerative colitis patients. This decrease predicted endoscopic and clinical remission, highlighting its utility in monitoring treatment response.
Area of Science:
- Gastroenterology
- Immunology
- Pharmacology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Monitoring disease activity and treatment response in UC is crucial.
- Faecal calprotectin is a validated biomarker for intestinal inflammation.
Purpose of the Study:
- To assess the impact of infliximab induction therapy on faecal calprotectin levels in UC patients.
- To determine if early changes in calprotectin correlate with treatment outcomes.
Main Methods:
- Prospective study of 53 active UC patients treated with infliximab (5 mg/kg) at weeks 0, 2, and 6.
- Weekly measurement of faecal calprotectin.
- Sigmoidoscopy at baseline, week 6, and week 10 to assess endoscopic remission.
Main Results:
- Median calprotectin levels significantly decreased from 1260 to 72.5 (p<0.001) by week 10.
- 58% of patients achieved endoscopic remission and significant calprotectin reduction (<50 mg/kg or ≥80% decrease).
- Early calprotectin decrease at week 2 predicted week 10 endoscopic remission (p<0.001).
Conclusions:
- Infliximab therapy induces a rapid and significant reduction in faecal calprotectin in anti-TNF-naïve UC patients.
- Faecal calprotectin decrease is predictive of disease remission.
- Calprotectin levels correlate strongly with endoscopic and clinical remission.
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