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Yeuhchukene--an indole derivative interacting with guinea pig reproduction
M Hammarström1, L Venemalm, J Bergman
1Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
The American Journal of Chinese Medicine
|January 1, 1990
Abstract:
Natural yuehchukene in doses of 10 mg/kg/day induced a 40% reduction of pregnancies in the guinea pig as compared with controls (p less than 0.05). Yuehchukene also caused a reduction in litter size which, however, was not significant indicating limited toxicity of the drug. An inhibition of ovum fertilization and/or implantation is suggested as the mechanism of action.