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Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Anaemia and iron deficiency in children with inflammatory bowel disease
Anthony E Wiskin1, Ben J Fleming, Stephen A Wootton
1NIHR Biomedical Research Unit (Nutrition, Diet & Lifestyle), Southampton General Hospital, SO16 6YD, UK.
Insights
Children with Inflammatory Bowel Disease (IBD) often have persistent anemia and iron deficiency. These conditions remain prevalent two years post-diagnosis, indicating a need for ongoing management.
Area of Science:
- Pediatric Gastroenterology
- Hematology
- Chronic Disease Management
Background:
- Anemia and iron deficiency are frequent in pediatric Inflammatory Bowel Disease (IBD).
- The impact of diagnosis on the prevalence of these conditions in children with IBD was previously unknown.
Purpose of the Study:
- To investigate the changes in prevalence of anemia and iron deficiency in children diagnosed with IBD over a two-year follow-up period.
Main Methods:
- Retrospective analysis of laboratory results from children with IBD at diagnosis and at one and two years post-diagnosis.
- Utilized World Health Organization (WHO) standards for anemia and published guidelines for iron deficiency.
Main Results:
- At diagnosis, 75% of pediatric IBD patients were anemic, decreasing to 30% at two-year follow-up.
- Iron deficiency was highly prevalent at diagnosis (90% in Crohn's disease, 95% in Ulcerative Colitis).
- At two-year follow-up, iron deficiency persisted in 70% of Crohn's disease and 65% of Ulcerative Colitis patients.
Conclusions:
- Anemia and iron deficiency are persistent issues in children with IBD.
- The prevalence of anemia and iron deficiency changes over time following diagnosis in pediatric IBD patients.
Background And Aims:
Anaemia and iron deficiency are common in children with Inflammatory Bowel Disease (IBD) however it is not known if the prevalence of anaemia and iron deficiency alters following diagnosis.
Methods:
Laboratory results from diagnosis, and at follow up one and two years later were recorded retrospectively in children with IBD recruited from a tertiary centre. Anaemia was defined using WHO standards and iron deficiency defined using published guidelines.
Results:
46 children (16 girls) with Crohn's disease and 34 children (18 girls) with UC were studied. 75% of children with IBD were anaemic at diagnosis, 30% were anaemic at follow up two years later. 90% of children with Crohn's and 95% of children with Ulcerative Colitis (UC) were iron deficient at diagnosis. At follow up two years later 70% of children with Crohn's and 65% of children with UC were iron deficient.
Conclusions:
Persistent anaemia and iron deficiency are common in childhood IBD, prevalence alters with duration of time from diagnosis.
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