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Related Experiment Video

Updated: May 24, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

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Common pathways for growth and for plasticity.

Shira Knafo¹, José A Esteban

¹Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, Madrid 28049, Spain. sknafo@cbm.uam.es

Current Opinion in Neurobiology

|March 9, 2012

Summary

This summary is machine-generated.

Cell growth and synaptic plasticity share common signaling pathways. These molecular mechanisms, including the Ras-PI3K pathway, influence cell division, differentiation, and synapse strength.

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Published on: September 20, 2024

Area of Science:

Neuroscience
Cell Biology
Molecular Biology

Background:

Cell growth and differentiation in developing tissues and synaptic plasticity in mature neurons appear distinct.
However, emerging evidence highlights shared intracellular signaling events between these processes.

Purpose of the Study:

To review recent findings on shared intracellular signaling mechanisms in cell proliferation, differentiation, and synaptic plasticity.
To elucidate how common pathways mediate distinct cellular outcomes.

Main Methods:

Review of latest research findings.
Focus on two prototypical signaling mechanisms: Ras-PI3K pathway and neural cell adhesion molecule signaling.

Main Results:

Identified shared intracellular signaling pathways in diverse cellular processes.
Highlighted the Ras-PI3K pathway as a key mediator.
Examined signaling from neural cell adhesion molecules interacting with growth factor receptors.

Conclusions:

Common signaling pathways play crucial roles in both developmental processes and neuronal plasticity.
Further elucidation of these shared mechanisms is needed to understand their diverse functional outcomes.