Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 24, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

A CT-analogous scheme for time-domain diffuse fluorescence tomography.

Feng Gao1, Jiao Li, Wei Zhang

  • 1College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China. gaofeng@tju.edu.cn

Journal of X-Ray Science and Technology
|March 9, 2012
PubMed
Summary

This study introduces a novel fiber-based, non-contact method for advanced fluorescence tomography. The technique enhances image quality by combining time-correlated single photon counting with a CT-analogous setup.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial.

Trials·2009
Same author

Long-term assessment of bladder and bowel dysfunction after radical hysterectomy.

Gynecologic oncology·2009
Same author

Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells.

Toxicology in vitro : an international journal published in association with BIBRA·2009
Same author

A rapid and simple method for identifying Mycobacterium tuberculosis W-Beijing strains based on detection of a unique mutation in Rv0927c by PCR-SSCP.

Microbes and infection·2009
Same author

CO oxidation over AuPd(100) from ultrahigh vacuum to near-atmospheric pressures: the critical role of contiguous Pd atoms.

Journal of the American Chemical Society·2009
Same author

Daunorubicin-loaded magnetic nanoparticles of Fe(3)O(4) greatly enhance the responses of multidrug-resistant K562 leukemic cells in a nude mouse xenograft model to chemotherapy.

Zhongguo shi yan xue ye xue za zhi·2009

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photonics

Background:

  • Diffuse fluorescence tomography (DFT) is crucial for non-invasive tissue characterization.
  • Existing DFT methods face challenges in sensitivity and data acquisition.
  • Non-contact measurement is desirable for patient comfort and reduced artifacts.

Purpose of the Study:

  • To develop and validate a fiber-based, non-contact scheme for time-domain diffuse fluorescence yield and lifetime tomography.
  • To enhance image quality and data acquisition efficiency in DFT.

Main Methods:

  • Utilized time-correlated single photon counting (TCSPC) for high-sensitivity, time-resolved detection.
  • Employed a computed tomography (CT)-analogous configuration for efficient, large-scale data collection.

More Related Videos

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
16:44

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

Related Experiment Videos

Last Updated: May 24, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
16:44

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

  • Performed pilot validation using both simulated and experimental two-dimensional (2D) data.

    • Main Results:

    • The proposed fiber-based, non-contact scheme successfully acquired time-resolved fluorescence data.
    • Validation demonstrated the method's capability in reconstructing fluorescence yield and lifetime.
    • Significant improvements in image quality were observed compared to conventional approaches.

    Conclusions:

    • The developed fiber-based, non-contact time-domain diffuse fluorescence tomography scheme is effective.
    • This methodology shows promise for advancing non-invasive biomedical imaging applications.
    • The combination of TCSPC and CT-analogous configuration enhances DFT performance.