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Related Experiment Video

Updated: May 24, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Functional self-assembled DNA nanostructures for molecular recognition.

Xiaojuan Zhang1, Vamsi K Yadavalli

  • 1Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.

Nanoscale
|March 9, 2012
PubMed
Summary

Researchers developed a programmable DNA self-assembly method to create aptamer-tagged nanostructures for molecular recognition. These stable, easily produced DNA shapes can bind specific protein targets in aqueous solutions.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • Nucleic acids offer versatile structural motifs for advanced nanoconstruction.
  • DNA self-assembly is a key technique for creating functional nanostructures.
  • Aptamers, when attached to DNA scaffolds, enable molecular recognition capabilities.

Purpose of the Study:

  • To present a facile and programmable strategy for assembling discrete aptamer-tagged DNA nanostructures.
  • To demonstrate the utility of these nanostructures for molecular recognition and binding in aqueous environments.
  • To enable on-demand production of diverse DNA shapes for protein binding or catalysis.

Main Methods:

  • Utilizing DNA self-assembly to create core shapes.
  • Programming the attachment of aptamers to DNA scaffolds.

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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Related Experiment Videos

Last Updated: May 24, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

  • Synthesizing and characterizing aptamer-tagged DNA nanostructures.
  • Testing the binding capabilities of nanostructures against specific protein targets.

    • Main Results:

    • Successful assembly of discrete aptamer-tagged DNA shapes and nanostructures.
    • Demonstrated molecular recognition and binding of two different protein targets.
    • Nanostructures exhibit stability and portability for long-term use.
    • Facile synthesis allows for large-scale, on-demand production.

    Conclusions:

    • The presented strategy offers a programmable and facile method for DNA nanoconstruction.
    • Aptamer-tagged DNA nanostructures are effective tools for molecular recognition and binding.
    • This approach facilitates the creation of diverse nanostructures for various applications, including protein binding and catalysis.