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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Sweet's syndrome with panuveitis resembling Behçet's disease
Wataru Matsumiya1, Sentaro Kusuhara, Yozo Yamada
1Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, 650-0017, Japan.
Japanese Journal of Ophthalmology
|March 9, 2012
Summary
Sweet's syndrome (SS), a skin condition, can cause severe eye inflammation (panuveitis) that mimics Behçet's disease (BD). Early recognition is crucial for accurate diagnosis and management of SS ocular symptoms.
Area of Science:
- Ophthalmology
- Dermatology
- Rheumatology
Background:
- Sweet's syndrome (SS) is an inflammatory skin disorder.
- It is characterized by fever, neutrophilia, and painful skin plaques.
- SS can sometimes involve ocular structures, including posterior uveitis.
Observation:
- Two cases of SS presenting with panuveitis are described.
- Patients exhibited symptoms mimicking Behçet's disease (BD).
- Ocular findings included severe iritis, hypopyon, and characteristic fluorescein angiography patterns.
Findings:
- Both patients were diagnosed with SS based on clinical and histopathological findings.
- Ocular manifestations in both cases were severe and bilateral.
- Fluorescein angiography revealed optic disc and macular/peripheral capillary leakage.
Implications:
- Differentiating SS from BD based solely on ocular findings can be challenging.
- Ophthalmologists must consider SS in the differential diagnosis of panuveitis.
- This highlights the importance of a multidisciplinary approach in managing complex inflammatory conditions.
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