Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.

Neuroscience research·2015
Same author

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.

Human molecular genetics·2015
Same author

Human somatic stem cell-based therapy for cartilage regeneration.

Annals of translational medicine·2015
Same author

Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.

Stem cells translational medicine·2015
Same author

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.

Molecular brain·2015
Same author

Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration.

Stem cells (Dayton, Ohio)·2015

Related Experiment Video

Updated: May 24, 2026

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

Notch signaling and the developing inner ear.

Junko Murata1, Katsuhisa Ikeda, Hideyuki Okano

  • 1Department of Otorhinolaryngology, Junteno University School of Medicine, Tokyo, Japan. jmurata@juntendo.ac.jp

Advances in Experimental Medicine and Biology
|March 9, 2012
PubMed
Summary

Notch signaling is crucial for inner ear development, guiding the formation of sensory hair cells (HCs) and supporting cells (SCs) through lateral inhibition and other inductive roles. Further research is needed to fully understand its complex functions.

More Related Videos

Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve
11:27

Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve

Published on: March 18, 2013

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Related Experiment Videos

Last Updated: May 24, 2026

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve
11:27

Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve

Published on: March 18, 2013

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Neuroscience

Background:

  • Sensory hair cells (HCs) and supporting cells (SCs) form a mosaic pattern in the inner ear.
  • Notch signaling, particularly its lateral inhibition function, is implicated in this pattern formation.
  • Delta-like1 and Jagged2 ligands are key players in cell diversification.

Purpose of the Study:

  • To survey studies on Notch signaling in inner ear development.
  • To discuss the inductive role of Notch signaling in prosensory region determination.
  • To explore Notch pathway functions during neuroblast delamination.

Main Methods:

  • Review of existing experimental data and gene expression patterns.
  • Analysis of functional studies on Notch-related genes.
  • Examination of ligand roles (Delta-like1, Jagged1, Jagged2).

Main Results:

  • Notch signaling mediates lateral inhibition for HC/SC mosaic pattern.
  • Jagged1 is essential for Notch-mediated prosensory region determination.
  • The Notch pathway regulates neuroblast delamination in early ear development.

Conclusions:

  • Notch signaling has diverse roles in inner ear development, including inhibition and induction.
  • While significant progress has been made, several aspects require further investigation.
  • Future research will focus on elucidating the remaining questions in Notch pathway functions.