Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Drug combination choices of 5α-reductase inhibitors and α-blockers in patients with benign prostatic hyperplasia: a study based on the FAERS database.

Frontiers in medicine·2026

Same author

Bidirectional Mendelian Randomization and Single‑Cell RNA Sequencing Reveal an NK Cell-Mediated Causal Link Between Endometriosis and Endometrial Cancer.

International journal of women's health·2026

Same author

NQO1-Mediated Anoikis Resistance and Immune Evasion Define a High-Risk Multi-Omic Subtype for Precision Management of T1 High-Grade Bladder Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Efficacy and safety of RC48 alone or combined with PD-1 inhibitors in high-risk non-muscle invasive bladder cancer.

Scientific reports·2026

Same author

RBM15 drives bladder cancer progression through YTHDF2-dependent m6A-mediated regulation of ZO2.

Journal of experimental & clinical cancer research : CR·2026

Same author

Non-Invasive Urine-Based Diagnostic Technologies for Early Bladder Cancer.

Biosensors·2026

Search research articles

Related Experiment Video

Updated: May 24, 2026

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Published on: January 7, 2019

Challenges for heart disease stem cell therapy.

Jane Hoover-Plow¹, Yanqing Gong

¹Departmentof Cardiovascular Medicine, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA. hooverj@ccf.org

Vascular Health and Risk Management

|March 9, 2012

Summary

Stem cell therapy shows promise for heart disease recovery after myocardial infarction (MI), but challenges remain. Optimizing stem cell identification, recruitment, and survival is key to improving cardiac function and patient outcomes.

Keywords:

engraftment expansion homing mobilization survival

More Related Videos

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Related Experiment Videos

Last Updated: May 24, 2026

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Published on: January 7, 2019

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Area of Science:

Regenerative Medicine
Cardiovascular Research
Stem Cell Biology

Background:

Cardiovascular diseases (CVDs) are a leading global cause of mortality.
Stem cell therapy is an emerging strategy for cardiac repair post-myocardial infarction (MI).
Current clinical trials show limited efficacy, with less than half reporting significant improvements in cardiac function.

Purpose of the Study:

To provide an overview of stem cell therapy for CVD.
To discuss key challenges hindering the optimization of stem cell therapy for heart disease.
To highlight novel strategies being developed to enhance therapeutic efficacy.

Main Methods:

Review of clinical trials using various stem cell sources (bone marrow, peripheral blood, umbilical cord blood).
Analysis of approaches involving stem cell mobilization agents.
Examination of strategies for improving stem cell survival and engraftment.

Main Results:

Stem cell therapy for MI has yielded modest improvements in cardiac function in many trials.
Commonly used stem cells include bone marrow, peripheral blood, and umbilical cord blood cells.
Mobilizing agents alone have also been tested for recruiting endogenous stem cells.

Conclusions:

Significant challenges exist in identifying, recruiting, and expanding autologous stem cells.
Development of effective mobilizing and homing agents is crucial for enhancing stem cell recruitment.
Improving the survival and engraftment of both endogenous and exogenous stem cells is essential for maximizing therapeutic benefits in CVD.