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Updated: May 24, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
Published on: February 10, 2014
Responsive hydrogels for label-free signal transduction within biosensors
Kamila Gawel1, David Barriet, Marit Sletmoen
1Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway. kamila.gawel@ntnu.no
Abstract:
Hydrogels have found wide application in biosensors due to their versatile nature. This family of materials is applied in biosensing either to increase the loading capacity compared to two-dimensional surfaces, or to support biospecific hydrogel swelling occurring subsequent to specific recognition of an analyte. This review focuses on various principles underpinning the design of biospecific hydrogels acting through various molecular mechanisms in transducing the recognition event of label-free analytes. Towards this end, we describe several promising hydrogel systems that when combined with the appropriate readout platform and quantitative approach could lead to future real-life applications.

