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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: May 24, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

Progress in personalizing chemotherapy for bladder cancer.

James S Chang1, Primo N Lara, Chong-Xian Pan

  • 1Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA 95817, USA.

Advances in Urology
|March 9, 2012
PubMed
Summary
This summary is machine-generated.

Predicting chemotherapy response in advanced bladder cancer is crucial. New methods measuring platinum-induced DNA damage may identify chemoresistance, paving the way for personalized bladder cancer treatments.

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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

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Last Updated: May 24, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Platinum-based chemotherapy is a standard treatment for advanced bladder cancer.
  • Currently, no reliable methods exist to predict patient response to chemotherapy.
  • Understanding bladder cancer biology is key to developing predictive biomarkers.

Purpose of the Study:

  • To explore novel methods for predicting chemotherapy response in bladder cancer.
  • To investigate the potential of molecular biomarkers for guiding treatment decisions.
  • To assess a microdosing approach for identifying chemoresistance.

Main Methods:

  • Investigating platinum-induced DNA damage as a marker of response.
  • Utilizing highly sensitive accelerator mass spectrometry technology for microdosing.
  • Evaluating emerging molecular biomarkers for clinical application.

Main Results:

  • Platinum drugs exert their effect by inducing DNA damage in cancer cells.
  • A microdosing approach is under investigation to detect chemoresistance.
  • Promising biomarkers require further validation in prospective trials.

Conclusions:

  • Accurate prediction of chemotherapy response in bladder cancer remains a significant challenge.
  • Measuring platinum-induced DNA damage shows potential for identifying chemoresistance.
  • Further research and validation are needed to implement personalized therapy for advanced bladder cancer.