Related Experiment Video

Updated: May 24, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

Howard H Chen1, Hushan Yuan, Lee Josephson

  • 11. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA.

Theranostics
|March 9, 2012
PubMed

Insights

This review explores molecular imaging techniques for key cell death regulators like PI3-kinase, AKT, and caspase-3. It highlights theranostic approaches for modulating these targets in cell death signaling.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Cell death involves complex signaling cascades with significant crosstalk.
  • Key pro-survival and pro-death molecules, including PI3-kinase, AKT, and caspase-3, have been identified.
  • Understanding these pathways is crucial for therapeutic interventions.

Purpose of the Study:

  • To review current molecular imaging approaches for key cell death targets.
  • To focus on theranostic strategies involving kinase and protease activity modulation.
  • To provide insights into advanced imaging and therapeutic targeting.

Main Methods:

  • Literature review of molecular imaging techniques.
  • Analysis of studies focusing on PI3-kinase, AKT, and caspase-3.
  • Examination of theranostic approaches for modulating target activity.

Main Results:

  • Various molecular imaging methods are available for visualizing cell death players.
  • Theranostic strategies offer potential for simultaneous imaging and treatment.
  • Modulating kinases and proteases presents a promising avenue for cancer therapy.

Conclusions:

  • Molecular imaging of cell death targets is advancing rapidly.
  • Theranostic approaches hold significant promise for personalized medicine.
  • Further research into kinase and protease modulation is warranted for improved cancer treatment.
Keywords:
ApoptosisCell DeathMolecular ImagingPI3KTheranostic

More Related Videos

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Evaluation of Caspase Activation to Assess Innate Immune Cell Death10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include: