Related Experiment Video
Updated: May 24, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Nitrox permits direct exit for attendants during extended hyperbaric oxygen treatment
Agneta C Larsson1, Johan Uusijärvi, Oskar Frånberg
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. agneta.larsson@ki.se
Hyperbaric oxygen protocol for attendants using nitrox (oxygen-enriched air) allows longer treatments up to 200 minutes at 2.8 ATA. This method reduced symptoms in attendants compared to local treatment protocols, with no reported complications.
Area of Science:
- Hyperbaric Medicine
- Physiology
- Respiratory Therapy
Background:
- Multiplace hyperbaric chambers require protocols for attendant safety and patient treatment.
- Nitrox (60.5% O2) enables extended hyperbaric oxygen treatments (HOPAN) up to 200 minutes at 2.8 ATA.
- HOPAN allows direct decompression, enhancing operational flexibility.
Purpose of the Study:
- To evaluate the safety and efficacy of the Hyperbaric Oxygen Protocol for Attendants using Nitrox (HOPAN).
- To compare attendant comfort and symptom incidence between HOPAN and local treatment protocols (LTP).
- To assess patient outcomes following hyperbaric oxygen treatment (HBO2T) managed under HOPAN.
Main Methods:
- HOPAN protocol involved cycles of nitrox breathing and chamber air for attendants.
- Data collected from 88 HOPAN sessions involving 59 attendants and 30 patients (2007-2009).
- Attendant perceptions were gathered via anonymous enquiry; patient records were reviewed for six months post-HBO2T.
Main Results:
- HOPAN sessions ranged from 55-167 minutes (median 140 minutes).
- Attendant comfort was comparable between HOPAN and LTP.
- Significantly fewer symptoms (paresthesias, joint pain) reported with HOPAN versus LTP; no complications documented for attendants or patients.
Conclusions:
- Nitrox breathing for hyperbaric chamber attendants facilitates flexible HBO2T up to 200 minutes at 2.8 ATA within no-decompression limits.
- HOPAN appears to be a safe and comfortable protocol for attendants, potentially reducing treatment-related symptoms.
- Findings support further research into HOPAN for optimizing hyperbaric oxygen therapy dosage and protocols.
More Related Videos
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Related Concept Videos
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils, connected...
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes: