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Related Experiment Videos

Twin-twin transfusion syndrome.

M A Urig1, W H Clewell, J P Elliott

  • 1Department of Obstetrics and Gynecology, Good Samaritan Medical Center, Phoenix, Arizona.

American Journal of Obstetrics and Gynecology
|November 1, 1990
PubMed
Summary

Twin-twin transfusion syndrome (TTTS) is a severe pregnancy complication with high mortality. Early intervention with repeated therapeutic amniocenteses shows promising benefits for affected twins.

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Area of Science:

  • Perinatology
  • Maternal-Fetal Medicine
  • High-Risk Obstetrics

Background:

  • Twin-twin transfusion syndrome (TTTS) presents with severe polyhydramnios and oligohydramnios in monochorionic twins.
  • TTTS diagnosed between 18-28 weeks gestation carries a near 100% perinatal mortality rate without intervention.

Purpose of the Study:

  • To evaluate the efficacy of therapeutic interventions for TTTS.
  • To assess the impact of repeated amniocenteses on perinatal outcomes in TTTS patients.

Main Methods:

  • Retrospective review of 19 TTTS patients treated over 5 years.
  • Intervention involved various therapeutic modes, with a focus on repeated amniocenteses.
  • Amniocenteses were performed before severe maternal complications like abdominal distention or labor.

Main Results:

  • Active intervention strategies were implemented due to high expected mortality.
  • Repeated therapeutic amniocenteses demonstrated beneficial effects.
  • Early intervention before severe maternal symptoms appeared to be key.

Conclusions:

  • Active management of TTTS is crucial given the high mortality associated with non-intervention.
  • Repeated therapeutic amniocenteses represent a potentially beneficial treatment modality for TTTS.
  • Timely intervention with amniocentesis before significant maternal distress improves outcomes.

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