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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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CD70 expression patterns in renal cell carcinoma.

Lucia B Jilaveanu1, Joshua Sznol, Saadia A Aziz

  • 1Department of Medicine, Section of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.

Human Pathology
|March 10, 2012
PubMed
Summary
This summary is machine-generated.

CD70 is elevated in kidney tumors, particularly clear cell and sarcomatoid subtypes. This suggests CD70 may be a viable therapeutic target for renal cell carcinoma treatment.

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Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • CD70 is upregulated in various cancers, promoting immune evasion by affecting lymphocytes.
  • Targeting CD70 is a promising therapeutic strategy, with agents in clinical trials.

Purpose of the Study:

  • To characterize CD70 protein expression in different renal cell carcinoma (RCC) subtypes.
  • To evaluate the prognostic significance of CD70 expression in RCC.
  • To explore associations between CD70 expression and clinical/pathologic variables.

Main Methods:

  • Utilized tissue microarrays from 330 RCC cases.
  • Employed a novel fluorescent immunohistochemistry-based Automated Quantitative Analysis (AQUA) for in situ protein expression.
  • Analyzed CD70 expression across various RCC histologic subtypes.

Main Results:

  • CD70 expression was significantly higher in tumor tissues compared to normal kidney tissue (P < .0001).
  • Elevated CD70 levels were observed in clear cell and sarcomatoid RCC subtypes (P < .0001), and variably in oncocytomas and papillary tumors.
  • High CD70 expression showed a trend towards decreased survival in clear cell RCC on univariate analysis but was not significant in multivariate analysis. No association with stage or grade was found.

Conclusions:

  • CD70 is frequently overexpressed in several renal cell carcinoma subtypes, including clear cell and sarcomatoid.
  • The elevated expression suggests CD70 is a potential therapeutic target for renal cell carcinoma.
  • Further research is needed to correlate CD70 expression with treatment response to CD70-targeting therapies in RCC.