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Extracellular Vesicle Tissue Factor Activity Assay
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Tissue factor controversies

Kenneth G Mann1, Jolanta Krudysz-Amblo, Saulius Butenas

  • 1University of Vermont, Department of Biochemistry, Burlington, VT, [corrected] USA. Kenneth.Mann@uvm.edu

Thrombosis Research
|March 10, 2012
PubMed

Tissue factor plays a primary role in both hemorrhage control and thrombosis depending upon whether its presentation is extravascular or intravascular. The molecular architecture and function of the tissue factor molecule and its role in the activations of factor IX and factor X have been elegantly elucidated but controversies prevail with respect to distinctions between tissue factor sources and tissue factor "activity." This presentation will review data on the architecture and functions of the tissue factor-factor VIIa complex and discuss the elements of the controversies associated with tissue factor presentation in both normal and pathologic milieu.

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