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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

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Related Experiment Video

Updated: May 24, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

MicroRNAs in B cell development and malignancy.

Thilini R Fernando1, Norma I Rodriguez-Malave, Dinesh S Rao

  • 1Department of Pathology and Laboratory Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Journal of Hematology & Oncology
|March 10, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs regulate gene expression and are vital for B cell development and health. Understanding these microRNAs (miRNAs) and their roles in B cell diseases can lead to new treatments.

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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression.
  • miRNAs play critical roles in B cell development, activation, and differentiation.
  • Dysregulation of miRNA expression is implicated in B cell malignancies and autoimmune diseases.

Purpose of the Study:

  • To review the role of miRNAs in normal B cell development.
  • To discuss miRNAs involved in B cell activation and differentiation.
  • To examine miRNAs dysregulated in B cell diseases, including cancer and autoimmunity.

Main Methods:

  • Literature review of scientific publications on microRNAs and B cells.
  • Analysis of studies on miRNA function in B cell development and disease.
  • Synthesis of current knowledge on miRNA targets and therapeutic potential.

Main Results:

  • Specific miRNAs are essential for proper B cell development in bone marrow.
  • miRNAs regulate key processes during B cell activation and terminal differentiation in the periphery.
  • Altered miRNA expression patterns are observed in various B cell malignancies and autoimmune conditions.

Conclusions:

  • Further research into miRNAs and their targets will enhance understanding of B cell biology.
  • Investigating miRNAs offers potential for developing novel therapeutic strategies for B cell-related diseases.