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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

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Published on: July 13, 2019

BK polyomavirus: emerging pathogen.

Shauna M Bennett¹, Nicole M Broekema, Michael J Imperiale

¹Program in Cellular and Molecular Biology, University of Michigan Medical School, 1150 West Medical Center Drive, 5724 Medical Science II, Ann Arbor, MI 48109-5620, USA.

Microbes and Infection

|March 10, 2012

Summary

BK polyomavirus (BKPyV) is a significant pathogen in immunocompromised patients, causing serious diseases like nephropathy and hemorrhagic cystitis. This review covers BKPyV

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Area of Science:

Virology
Immunology
Infectious Diseases

Background:

BK polyomavirus (BKPyV) is a common virus, typically latent in most individuals.
Immune suppression can lead to BKPyV reactivation and significant disease.
BKPyV is an emerging pathogen, particularly in transplant recipients.

Purpose of the Study:

To review the clinical significance of BKPyV.
To discuss the impact of BKPyV on the host.
To outline the virus life cycle and current treatment strategies.

Main Methods:

Literature review of clinical studies and virological research.
Synthesis of information on BKPyV pathogenesis and clinical manifestations.
Analysis of current therapeutic approaches for BKPyV infections.

Main Results:

BKPyV causes polyomavirus-associated nephropathy in renal transplant patients.
BKPyV leads to hemorrhagic cystitis in bone marrow transplant patients.
Reactivation is linked to immune suppression and lytic infection.

Conclusions:

BKPyV poses a substantial clinical threat to immunocompromised individuals.
Understanding BKPyV's life cycle is crucial for developing effective treatments.
Current treatment protocols aim to manage BKPyV-associated diseases.