Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Sevoflurane Concentration, Blood Pressure, Arterial Carbon Dioxide Tension, Temperature, and Stimulation on Spinal Cord Blood Flow in Patients Undergoing Spinal Surgery: An Exploratory Study.

Anesthesiology·2026
Same author

A Population-Based Cohort Study of Early Infant Feeding Initiation in Maternal Bipolar Disorder.

Bipolar disorders·2025
Same author

Spinal Cord Blood Flow, Metabolism, and Neurological Outcome in Patients with Acute, Severe Traumatic Spinal Cord Injuries.

Neurocritical care·2025
Same author

Current and novel approaches for critical care management of aneurysmal subarachnoid hemorrhage in critical care.

Current opinion in anaesthesiology·2025
Same author

Evolution of Spinal Cord Swelling in Acute Traumatic Spinal Cord Injury.

Neurotrauma reports·2025
Same author

The current state of cranioplasty in Europe - Results from a European cranioplasty survey.

Brain & spine·2025

Related Experiment Video

Updated: May 24, 2026

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

Modified acrylic cranioplasty for large cranial defects.

Melissa C Werndle1, Matthew Crocker, Argyro Zoumprouli

  • 1Academic Neurosurgery Unit, St George's, University of London, and Department of Neuroanaesthesia, St George's Hospital, London SW17 0RE, UK.

Clinical Neurology and Neurosurgery
|March 10, 2012
PubMed
Summary

This study introduces a new method for repairing large cranial defects using a modified acrylic cranioplasty technique. The approach involves using a bony rim from the skull defect as a scaffold to shape acrylic cement away from the brain, avoiding thermal injury. The acrylic is formed into a dome that fits snugly with the bony rim and is attached using bioplates. The technique was tested in three patients and found to be cheaper and immediately available compared to titanium implants. The cosmetic results were similar to titanium cranioplasty, and the method avoided brain injury during surgery. The authors suggest that this approach may be a viable alternative for treating large cranial defects.

Keywords:
Cranial defect repairAcrylic cranioplastyNeurosurgical reconstructionSurgical implant techniques

Frequently Asked Questions

More Related Videos

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity
10:05

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

Published on: May 7, 2017

Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals
06:25

Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals

Published on: January 19, 2024

Related Experiment Videos

Last Updated: May 24, 2026

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity
10:05

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

Published on: May 7, 2017

Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals
06:25

Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals

Published on: January 19, 2024

Area of Science:

  • Neurosurgical reconstruction techniques
  • Cranial defect repair in neurosurgery
  • Biomedical materials in surgical applications

Background:

Cranial defects often require reconstruction to restore skull integrity and appearance. Traditional methods use titanium implants, which are costly and require specialized manufacturing. Prior research has shown that titanium cranioplasty offers good cosmetic outcomes but is limited by high costs and availability delays. No prior work had resolved the issue of using more accessible and affordable materials for large defects. This gap motivated the development of alternative techniques using acrylic cement. Existing studies have focused on titanium and other metals, but no prior work had explored the use of acrylic cement in a modified way. The need for a cost-effective and readily available solution remains unmet. This paper introduces a novel acrylic-based approach to address these limitations.

Purpose Of The Study:

The aim of this study was to describe a new method for constructing polymethylmethacrylate-based cranioplasty to repair large cranial defects. The specific problem addressed is the high cost and limited availability of titanium implants. The motivation stems from the need for a more accessible and affordable alternative. The authors propose a technique that uses acrylic cement in a modified fashion. This method avoids thermal injury to the brain and reduces surgical time. The study also aims to compare the cost and outcomes of the acrylic method with titanium cranioplasty. The goal is to provide a viable alternative for neurosurgeons treating large cranial defects. The authors suggest that this approach may offer similar cosmetic results at a lower cost.

Main Methods:

The modified acrylic cranioplasty involves cutting a bony rim from the edge of the skull defect using a craniotome. This bony rim serves as a scaffold for shaping the acrylic cement away from the patient. The inner edge of the bony rim is drilled to create a groove. Acrylic cement is then filled into the groove and shaped into a dome-like structure. Continuous manipulation of the acrylic paste ensures proper contouring. The groove allows the acrylic dome to fit snugly with the bony rim. The final implant is attached to the skull using bioplates. The technique was tested in three patients with large cranial defects.

Main Results:

The modified acrylic cranioplasty was successfully used in three patients with large cranial defects. The technique produced a strong implant with excellent cosmetic outcomes. The acrylic dome fit snugly with the bony rim, avoiding issues like sinking. The method avoided thermal injury to the brain during surgery. Intraoperative blood loss was comparable to titanium cranioplasty. Operating theatre time was similar between the two techniques. The acrylic method was significantly cheaper than titanium implants. The authors report that the acrylic technique is quick and easy to perform.

Conclusions:

The authors conclude that modified acrylic cranioplasty is a viable alternative to titanium implants for large cranial defects. The technique is cheaper and immediately available compared to titanium cranioplasty. The cosmetic outcomes of the acrylic method are similar to those of titanium. The method avoids thermal injury to the brain and reduces surgical time. The snug fit of the acrylic dome with the bony rim prevents sinking. The authors suggest that this approach may be suitable for patients with large cranial defects. The technique is quick and easy to perform, making it accessible in various surgical settings. The findings indicate that acrylic cranioplasty can be a cost-effective and effective option.

The main advantage is that it is cheaper and immediately available compared to titanium cranioplasty.

The acrylic cement is shaped away from the patient, avoiding direct contact with the brain during the procedure.

The groove allows the acrylic dome to fit snugly with the bony rim, preventing sinking and ensuring stability.

Bioplates are used to firmly attach the final acrylic dome to the skull, ensuring structural integrity.

The operating theatre time is similar between the two techniques, with no significant difference reported.

The authors concluded that the cosmetic outcomes of the acrylic method are similar to those of titanium cranioplasty.