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Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Updated: May 24, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Prostate cancer stem cell biology.

C Yu¹, Z Yao, Y Jiang

¹Department of Urology and Pathology, University of Michigan, Ann Arbor, MI, USA.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology

|March 10, 2012

Summary

Cancer stem cells (CSCs) offer insights into cancer biology and treatment. This review explores prostate CSCs, their origins, markers, signaling pathways, metastasis, and microRNA regulation for potential PCa therapies.

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Area of Science:

Oncology
Cancer Biology

Background:

The cancer stem cell (CSC) model is a framework for understanding cancer pathophysiology and therapeutic responses.
While controversial, the CSC model is foundational for exploring cancer biology.

Purpose of the Study:

To provide an overview of CSC concepts, biology, and potential therapeutic strategies.
To focus on prostate CSCs, examining their origins, identification markers, signaling pathways, role in metastasis, and microRNA regulation.

Main Methods:

This is a review article, synthesizing existing research on cancer stem cells, with a specific focus on prostate cancer.

Main Results:

Prostate CSCs are explored concerning their potential origins (basal-derived or luminal-derived).
Key markers for identifying prostate CSCs are discussed.
Alterations in signaling pathways, the involvement in prostate cancer (PCa) metastasis, and microRNA-mediated regulation of prostate CSCs are examined.

Conclusions:

Definitive identification and characterization of prostate CSCs remain areas for further research.
Future research targeting CSCs may yield novel therapeutic strategies for prostate cancer treatment.