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Related Experiment Video

Updated: May 24, 2026

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Androgen action in the prostate gland.

N Yadav¹, H V Heemers

¹Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology

|March 10, 2012

Summary

Androgen receptor (AR) signaling is crucial for prostate health and prostate cancer (PCa) progression. Novel insights into AR action are improving therapeutic strategies for lethal castration-recurrent PCa.

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Androgen receptor (AR) signaling is essential for prostate development, function, and the progression of prostate cancer (PCa).
Androgen deprivation therapies (ADTs) are standard for advanced PCa but lead to lethal castration-recurrent (CR) disease.
CR PCa remains dependent on AR signaling despite low androgen levels.

Purpose of the Study:

To provide an overview of androgen action in prostate cancer.
To summarize recent advances in understanding AR signaling in PCa progression.
To discuss implications for optimizing PCa therapeutics.

Main Methods:

Review of current literature on AR signaling in prostate cancer.
Analysis of novel concepts in AR action, including metabolism, structure, function, and gene expression.

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Last Updated: May 24, 2026

Murine Prostate Micro-dissection and Surgical Castration

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Published on: May 11, 2016

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Published on: October 24, 2019

Discussion of therapeutic implications based on new findings.

Main Results:

AR signaling is critical throughout prostate cancer progression, even in CR disease.
New understanding of AR regulation involves intraprostatic metabolism, AR structure/function, tumor suppressors, oncogenes, non-transcriptional roles, and gene expression modes.
These insights enhance comprehension of AR-driven events leading to lethal PCa.

Conclusions:

Recent discoveries significantly advance our understanding of AR-dependent mechanisms in lethal prostate cancer.
Optimizing therapeutic interventions for PCa can be informed by these novel concepts of AR action.
Further research into AR regulation holds promise for improved treatment strategies.