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Related Experiment Videos

Bladder contributes to eicosanoids excreted in urine.

A A Reyes1, S Klahr

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

The American Journal of Physiology
|November 1, 1990
PubMed
Summary

Urine eicosanoid levels, including thromboxane B2 and prostaglandin E2, are higher when collected from the bladder compared to the ureter in rats. This indicates the bladder significantly contributes to urinary eicosanoid excretion.

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Area of Science:

  • Biochemistry
  • Urology
  • Physiology

Background:

  • Eicosanoids play crucial roles in various physiological processes.
  • Understanding eicosanoid excretion pathways is important for diagnosing and treating urinary tract conditions.

Purpose of the Study:

  • To investigate the contribution of the bladder to urinary eicosanoid excretion.
  • To compare eicosanoid levels in urine collected from the bladder versus the ureter in normal rats.

Main Methods:

  • Collected urine samples from the bladder and ureter of normal rats.
  • Quantified the excretion of specific eicosanoids, including thromboxane B2, prostaglandin E2, and 6-ketoprostaglandin F1 alpha.

Main Results:

  • Significantly higher excretion of thromboxane B2, prostaglandin E2, and 6-ketoprostaglandin F1 alpha was observed in bladder urine compared to ureter urine.

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  • Demonstrated a significant difference in eicosanoid concentrations between the two collection sites.

    • Conclusions:

    • The bladder significantly contributes to the overall eicosanoid content found in urine.
    • These findings suggest local production or modification of eicosanoids within the bladder itself.