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Updated: May 24, 2026

Bilayer Microfluidic Device for Combinatorial Plug Production
Published on: December 1, 2023
Experimental validation of plugging during drop formation in a T-junction.
Adam R Abate1, Pascaline Mary, Volkert van Steijn
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, Massachusetts, USA. adam.abate@ucsf.edu
Researchers experimentally observed pressure dynamics during T-junction drop formation. They confirmed the squeezing mechanism and discovered oscillating pressures in both fluids, indicating a combined squeezing-shearing mechanism even at high capillary numbers.
Area of Science:
- Fluid Dynamics
- Microfluidics
- Interfacial Science
Background:
- Drop formation in T-junctions at low capillary numbers is primarily governed by interfacial effects.
- The
- squeezing
- mechanism, where continuous fluid pressure pinches off dispersed fluid, is theoretically understood but experimentally unverified regarding pressure dynamics.
Purpose of the Study:
- To experimentally investigate and validate the pressure dynamics during T-junction drop formation.
- To identify the precise pressure changes responsible for drop pinch-off.
- To explore the influence of capillary number on pressure oscillations and the underlying formation mechanism.
Main Methods:
- Development and utilization of novel Laplace sensors for high-speed, localized pressure measurements within a T-junction.
- Empirical study of pressure variations in both continuous and dispersed fluid phases during the drop formation process.
- Analysis of pressure data across a range of capillary numbers to determine the dominant formation mechanisms.
Main Results:
- Experimental confirmation of the pressure rise predicted by the
- squeezing
- mechanism.
- Discovery of anti-phase pressure oscillations between the continuous and dispersed fluid phases.
- Observation that pressure oscillations persist even at high capillary numbers, indicating a combined formation mechanism.
Conclusions:
- The study validates the
- squeezing
- mechanism and provides the first experimental evidence of the associated pressure dynamics.
- Drop formation in confined geometries involves a combination of squeezing and shearing forces, not solely shear-driven, even under conditions favoring monodisperse drop production.
- The findings offer crucial insights into microfluidic drop generation and control.
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