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Neurogenesis of respiratory rhythm and pattern: emerging concepts
J L Feldman1, J C Smith, H H Ellenberger
1Department of Kinesiology, University of California, Los Angeles 90024-1527.
The American Journal of Physiology
|November 1, 1990
Summary
Neural control of mammalian breathing involves state-dependent mechanisms and separate rhythm/pattern generators. Conditional pacemaker cell activity may drive respiratory rhythm in reduced states.
Area of Science:
- Neuroscience
- Respiratory Physiology
Background:
- The nervous system intricately controls breathing in mammals.
- Understanding the neural basis of respiratory control is crucial for respiratory health.
Purpose of the Study:
- To propose three hypotheses regarding the neural control of breathing in mammals.
- To explore state-dependent changes in neural breathing mechanisms.
- To investigate the separation of respiratory rhythm and pattern generation.
Main Methods:
- Hypothetical framework development.
- Analysis of existing literature on respiratory neurobiology.
- Conceptual modeling of neural control mechanisms.
Main Results:
- Hypothesis 1: Neural breathing control mechanisms are state-dependent, involving modulation or transformation.
- Hypothesis 2: Mechanisms for respiratory rhythm and pattern generation are distinct.
- Hypothesis 3: Conditional pacemaker cell activity underlies respiratory rhythm in reduced states.
Conclusions:
- Breathing control is dynamic and state-influenced.
- Respiratory rhythm and pattern are generated by separate neural circuits.
- Pacemaker cell activity offers a potential basis for respiratory rhythm in simplified neural preparations.