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Related Experiment Video

Updated: May 24, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Neuromyelitis optica and pregnancy.

B Bourre¹, R Marignier, H Zéphir

¹Department of Neurology, Hôpital Charles Nicolle, Rouen, France. bertrand.bourre@chu-rouen.fr

|March 10, 2012

Summary

Pregnancy influences neuromyelitis optica (NMO) activity, necessitating close medical supervision. However, epidural analgesia and breastfeeding do not appear to worsen NMO in the postpartum period.

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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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Published on: April 14, 2014

Area of Science:

Neurology
Immunology
Reproductive Medicine

Background:

Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the central nervous system.
The impact of pregnancy on NMO course and postpartum management remains an area of clinical interest.

Purpose of the Study:

To evaluate how pregnancy affects neuromyelitis optica (NMO) activity.
To determine the influence of epidural analgesia and breastfeeding on NMO activity in the postpartum period.

Main Methods:

Retrospective analysis of patients diagnosed with NMO using Wingerchuk criteria.
Comparison of annualized relapse rates (ARR) before, during, and after pregnancy.
Assessment of disability using the Kurtzke Expanded Disability Status Scale (EDSS).

Main Results:

A trend towards increased NMO relapses was observed in the second trimester postpartum (PP2).
Epidural analgesia and breastfeeding did not demonstrate a significant impact on NMO course.
A significant increase in EDSS scores was noted from before pregnancy to one year postpartum.

Conclusions:

Pregnancy is a factor that influences neuromyelitis optica activity, warranting vigilant medical monitoring.
Current evidence does not support epidural analgesia or breastfeeding as aggravating factors for NMO.