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Related Experiment Video

Updated: May 24, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Reproducibility of different methods to measure the endothelial function.

Steven Onkelinx1, Veronique Cornelissen, Kaatje Goetschalckx

  • 1Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.

Vascular Medicine (London, England)
|March 10, 2012
PubMed
Summary

Flow-mediated dilatation (FMD) is more reliable than peripheral arterial tonometry (PAT) for assessing endothelial function in patients with coronary heart disease. FMD showed lower within-day variability, indicating better measurement consistency.

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Area of Science:

  • Cardiovascular Research
  • Medical Device Evaluation
  • Endothelial Function Assessment

Background:

  • Endothelial dysfunction is a key factor in coronary heart disease.
  • Accurate assessment of endothelial function is crucial for patient management.
  • Flow-mediated dilatation (FMD) and peripheral arterial tonometry (PAT) are common methods.

Purpose of the Study:

  • To compare the reliability and reproducibility of FMD and PAT.
  • To determine which method offers superior measurement consistency for endothelial function.

Main Methods:

  • Simultaneous FMD (brachial artery ultrasound) and PAT (EndoPAT 2000) measurements.
  • Testing conducted twice within a day and repeated two days later.
  • Analysis of within-day and between-day variability.

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Related Experiment Videos

Last Updated: May 24, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Main Results:

  • FMD exhibited lower within-day variability (10%) compared to PAT (18%; p < 0.05).
  • Between-day variability was similar for both methods (11%).
  • A significant correlation (r = 0.57, p < 0.001) was observed between PAT and FMD.

Conclusions:

  • FMD demonstrated superior reliability for within-day measurements compared to PAT.
  • FMD offers better measurement consistency for assessing endothelial function in coronary heart disease patients.
  • Both methods showed comparable between-day reliability.