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Myocardial infarction and generalised anxiety disorder: 10-year follow-up
Annelieke M Roest1, Marij Zuidersma, Peter de Jonge
1Department of Psychiatry, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Background:
Few studies have addressed the relationship between generalised anxiety disorder and cardiovascular prognosis using a diagnostic interview.
Aims:
To assess the association between generalised anxiety disorder and adverse outcomes in patients with myocardial infarction.
Method:
Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed up until 2007. Current generalised anxiety disorder and post-myocardial infarction depression were assessed with the Composite International Diagnostic Interview. The end-point consisted of all-cause mortality and cardiovascular-related readmissions.
Results:
During the follow-up period, 198 patients had an adverse event. Generalised anxiety disorder was associated with an increased rate of adverse events after adjustment for age and gender (hazard ratio: 1.94; 95% confidence interval: 1.14-3.30; P = 0.01). Additional adjustment for measures of cardiac disease severity and depression did not change the results.
Conclusions:
Generalised anxiety disorder was associated with an almost twofold increased risk of adverse outcomes independent demographic and clinical variables and depression.
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