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Claudication, in contrast to angina pectoris, independently predicts mortality risk in the general population

Arne G Kieback1, Roberto Lorbeer, Henri Wallaschofski

  • 1University Heart Center Hamburg-Eppendorf, Germany. akieback@uke.de

VASA. Zeitschrift Fur Gefasskrankheiten
|March 10, 2012
PubMed

Insights

Claudication, a symptom of peripheral artery disease, significantly predicts future mortality, unlike angina pectoris. This finding highlights the importance of recognizing claudication as a critical health indicator.

Area of Science:

  • Cardiovascular epidemiology
  • Public health research
  • Clinical risk stratification

Background:

  • Claudication and angina pectoris are symptoms that may indicate underlying cardiovascular disease.
  • Previous research has explored their association with mortality, but further investigation is warranted.

Purpose of the Study:

  • To determine if claudication and angina pectoris predict future all-cause and cardiovascular mortality.
  • To assess these symptoms as independent predictors after adjusting for major cardiovascular risk factors.

Main Methods:

  • Analysis of 3995 participants from the population-based Study of Health In Pomerania (SHIP).
  • Kaplan-Meier and multivariable Cox proportional hazards regression analyses were employed.
  • Outcomes assessed included all-cause and cardiovascular mortality over a median follow-up of 8.5 years.

Main Results:

  • Claudication was associated with a significantly higher fully-adjusted all-cause mortality rate (HR 1.79) and a higher sex- and age-adjusted cardiovascular mortality rate (HR 1.76).
  • Angina pectoris was not associated with elevated all-cause mortality (HR 1.15) or cardiovascular mortality (HR 0.71) after adjustment.
  • At baseline, 417 individuals reported angina pectoris and 323 reported claudication.

Conclusions:

  • Claudication is a strong, independent predictor of all-cause mortality.
  • In contrast, angina pectoris, as defined in this study, did not demonstrate predictive value for mortality.
  • These findings suggest claudication should be carefully evaluated for its prognostic implications.
Abstract

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