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Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells

Xuguang Tai1, François Van Laethem, Leonid Pobezinsky

  • 1Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

Blood
|March 10, 2012
PubMed
Summary

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) externalization grants suppressor function to both regulatory T cells (Tregs) and conventional T cells (Tconv). Intracellular localization is crucial for CTLA-4 protein function.

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