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Related Experiment Video

Updated: May 24, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

New antiviral agents for hepatitis C.

Jean-Michel Pawlotsky

F1000 Biology Reports

|March 10, 2012

Summary

New hepatitis C virus (HCV) therapies, including direct-acting antivirals and host-targeted agents, offer improved treatment options beyond traditional interferon therapy. These advancements target viral functions or host replication, advancing HCV cure possibilities.

Area of Science:

Hepatology
Virology
Pharmacology

Background:

Chronic hepatitis C virus (HCV) infection affects 120-130 million people globally, despite being curable.
Traditional treatment relied on pegylated interferon-α and ribavirin.
Development of HCV lifecycle models facilitated the discovery of novel antiviral agents.

Purpose of the Study:

To review direct-acting antivirals (DAAs) and host-targeted agents for HCV treatment.
To discuss the clinical development pathways of these new agents, with or without interferon-α.

Main Methods:

Review of recently approved and tested direct-acting antivirals targeting viral functions.
Examination of host-targeted agents, such as cyclophilin inhibitors, that inhibit HCV replication.

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Analysis of clinical trial data for agents used in combination with or without interferon-α.

Main Results:

Direct-acting antivirals include NS3-4A protease inhibitors (e.g., telaprevir, boceprevir), RNA-dependent RNA polymerase inhibitors, and NS5A inhibitors.
Host-targeted agents like cyclophilin inhibitors represent another therapeutic strategy.
Two primary clinical development paths exist: interferon-based and interferon-free regimens.

Conclusions:

Significant advancements in HCV therapy have been made with the development of DAAs and host-targeted agents.
These novel therapies offer more targeted approaches to inhibiting HCV replication.
The choice between interferon-containing and interferon-free regimens is a key consideration in current HCV treatment strategies.