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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: May 24, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Informatics enhanced SNP microarray analysis of 30 miscarriage samples compared to routine cytogenetics.

Ruth B Lathi¹, Jamie A M Massie, Megan Loring

¹Stanford Fertility and Reproductive Medicine Center, Palo Alto, California, United States of America. rlathi@stanford.edu

|March 10, 2012

Summary

Single nucleotide polymorphism (SNP) microarrays offer a faster and effective method for miscarriage karyotyping compared to traditional techniques. This molecular karyotyping approach accurately identifies chromosomal abnormalities and reduces diagnostic time.

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Published on: February 23, 2011

Area of Science:

Reproductive medicine
Genetics
Molecular diagnostics

Background:

Traditional metaphase karyotype is a standard diagnostic tool for early miscarriage.
Existing karyotyping methods have notable limitations impacting diagnostic efficiency.

Purpose of the Study:

To evaluate the efficacy of single nucleotide polymorphism (SNP) microarrays as a novel karyotyping technique.
To compare SNP microarray analysis against traditional metaphase karyotyping in a blinded, prospective study.

Main Methods:

Patients undergoing dilation and curettage for first-trimester miscarriage were enrolled.
Chorionic villi samples were divided for parallel SNP microarray and routine cytogenetic testing.

Main Results:

Thirty samples were analyzed, showing high concordance between SNP microarray and cytogenetic testing.
Discordant results were observed in cases of whole genome duplication or balanced rearrangements.
SNP microarray analysis yielded results significantly faster (12 days) than traditional karyotyping (29 days).

Conclusions:

SNP microarray analysis provides rapid and accurate molecular karyotyping of products of conception after missed abortion.
This method effectively detects maternal cell contamination.
It demonstrates good concordance with standard cytogenetic analysis, offering a superior alternative for miscarriage diagnosis.