Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Algorithm for assessing renal dysfunction risk in critically ill trauma patients receiving aminoglycosides.

B A Boucher1, B C Coffey, D A Kuhl

  • 1Department of Clinical Pharmacy, University of Tennessee, Memphis.

American Journal of Surgery
|November 1, 1990
PubMed
Summary

This study validates screening criteria for identifying critically ill trauma patients at risk of kidney dysfunction from aminoglycosides. The criteria effectively identify patients at low risk, guiding conservative management and alternative antibiotic use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventilator associated pneumonia caused by <i>Raoultella ornithinolytica</i> in two immunocompetent trauma patients.

Respiratory medicine case reports·2018
Same author

Damage control strategies in the management of acute injury.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2016
Same author

Long chain polyunsaturated fatty acid supplementation in infancy increases length- and weight-for-age but not BMI to 6 years when controlling for effects of maternal smoking.

Prostaglandins, leukotrienes, and essential fatty acids·2015
Same author

Improving outcomes of renal transplant recipients with behavioral adherence contracts: a randomized controlled trial.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Fruit and vegetable intake and bone health in women aged 45 years and over: a systematic review.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
Same author

Establishing a laparoscopic bariatric program in a safety net hospital.

Surgical endoscopy·2006

Area of Science:

  • Pharmacology
  • Nephrology
  • Critical Care Medicine

Background:

  • Aminoglycosides are crucial antibiotics for critically ill trauma patients.
  • Identifying patients at risk for aminoglycoside-induced renal dysfunction is vital for patient safety.
  • Previous retrospective studies proposed screening criteria for this risk.

Purpose of the Study:

  • To validate previously proposed screening criteria for renal dysfunction in trauma patients receiving aminoglycosides.
  • To develop a clinical algorithm based on validated criteria for risk assessment.
  • To identify key risk factors associated with renal dysfunction in this patient population.

Main Methods:

  • Retrospective validation study of critically ill trauma patients.
  • Inclusion of patients receiving aminoglycosides and a control group not receiving them.

Related Experiment Videos

  • Evaluation of renal dysfunction defined as serum creatinine increase ≥ 0.5 mg/dL.
  • Statistical analyses including univariate and multivariate methods.

    • Main Results:

    • Overall renal dysfunction incidence was 10% in aminoglycoside recipients vs. 5% in controls (p=0.13).
    • Screening criteria demonstrated 67% sensitivity and 92% specificity.
    • Negative predictive value was high (96%), identifying low-risk patients effectively.
    • Post-admission shock, high aminoglycoside serum concentration (>2 mg/L), and liver dysfunction were major risk factors.

    Conclusions:

    • The validated screening criteria, particularly post-admission shock, high serum concentration, and liver dysfunction, are valuable for identifying trauma patients at low risk of renal dysfunction.
    • High negative predictive value supports conservative management by enabling safe avoidance of aminoglycosides.
    • Alternative antimicrobial agents should be considered for patients identified as high risk.